Information on the thesis

Dissertation  is  devoted  to  the  investigation  of  prooxidant-antioxidant  balance  in
blood of patients with  first diagnosed destructive pulmonary  tuberculosis with bacterial,
features  of  influence  of  standardized  chemotherapy,  frequency  modulated  and
unmodulated He-Ne intravenous laser irradiation of blood (ILBI), ozonized saline solution
with  varying  concentrations  of  ozone  and  their  combinations  on  prooxidant-antioxidant
balance, level molecules of middle mass in the serum of blood. It was established that the
development  of  tuberculosis  is  characterized  by  a  significant  increase  of  the  activity  of
oxidative  processes  (DC,  TBA-PP,  PGE,  GOA),  decreased  activity  of  enzymes  of
antioxidant  system  (SOD,  catalase)  increased  levels  of  ceruloplasmin,  compared  with
healthy  donors.  In  patients  with  infiltrative  and  disseminated  tuberculosis  difference
between the  indices of prooxidant-antioxidant balance  in blood and  level of MMM was
detected. The use of chemotherapy does not ensure full recovery of the studied parameters
of prooxidant-antioxidant balance.
The  use  of  helium-neon  intravenous  laser  blood  irradiation  with  frequency
modulation  (5,0  kHz,  100,0  kHz)  leads  to  a  significant  decrease  lipid  peroxidation,
increased activity of enzymes of AOS and reduces of level of MMM in blood serum to
values observed in healthy donors. The effectiveness of influence ILBI on the prooxidant-
antioxidant  balance  did  not  change  significantly  with  decreasing  frequency  radiation
intensity from 1,0 to 3,0 kHz. The realization of effects of frequency modulation of laser
radiation depends on the character of and depth of the violations output values of  studied
parameters.
A positive effect of  use of the recovery prooxidant-antioxidant balance infusion of
ozone-oxygen mixture in saline with ozone concentration of 12 mg/l with different inputs
of the ozone (↑↓, ↑) it was detected.  It was established that the effectiveness of influence
of the combined use of chemo-ozone-lasertherapy on restoration of prooxidant-antioxidant
balance  depends  on  ozone  concentration  in  saline  and  frequency  modulation  of  He-Ne
laser.
The performed two-factor dispersive and cluster analysis of combined influence of
ozonized saline and laser in violation POL/AOS balance in patients blood with bacterial
lung  tuberculosis  under  chemotherapy  confirmed  the  effectiveness  of  these  modes
combined with use of chemo-laser-ozonetherapy.
Key words: laser, frequency modulation, ozonotherapy, chemotherapy, prooxidant-
antioxidant balance, patients with pulmonary tuberculosis.