THE INFLUENCE OF CARNOSINE, Zn-CARNOSINE AND TAURINE ON THE
LEVEL OF LACTATE AND PIRUVATE IN RAT'S BRAIN AT THE HYPOXIC
STRESS

O.Krys'ko, M.Boiko, V.Korobov, O.Kozak, M.Velykyi, A.Fedorovych

Ivan Franko National University of Lviv, Hrushevskyi St. 4,
UA-79005 Lviv, Ukraine. e-mail: kfbh@franko.lviv.ua

       The preliminary insertion of carnosine, Zn-carnosine and taurine before the hypoxic hypoxia lead to increasing of lactate and decreasing of piruvate in rat's brain in comparison with hypoxia. That it testify to these low-weight natural metabolites have prevented the development of acidose in brain at the hypoxic hypoxia. That effect is associated with pH-buffering properties of carnosine and Zn-carnosine. The antiacidosic effect of taurine is connected with stimulation of Ca2+-accumulative function of mitochondria.

       Key words: carnosine, Zn-carnosine, taurine, lactate, piruvate