CHARACTERIZATION OF RESISTANCE PATTERN TO ANTIBIOTICS OF
PRODUCERS OF ANTITUMOUR ANTIBIOTICS STREPTOMYCES
GLOBISPORUS 1912, STREPTOMYCES PEUCETIUS ATCC 29050 AND
STREPTOMYCES PEUCETIUS SUBSP. CAESIUS ATCC 27952
L. Dubytska, S. Zavorotna, B. Ostash, O. Gromyko, L. Basiliya, V. Fedorenko
Ivan Franko National University of Lviv, Hrushevskyi st.4,
UA-79005 Lviv, Ukraine, e-mail: genetic@franko.lviv.ua
Antibiotic resistance pattern has been studied in strains S. globisporus 1912 and S. peucetius ATCC 29050 and ATCC 27925. 50-100% S. globisporus spore survival was observed when medium contained 1-5 mg/ml of b-lactams, macrolides, tetracycline. The same level of spore survival, when using aminoglycosides, anthracyclines, rifampicin was indicated at more decreased concentrations ( less than 0.2mg/ml). Strain 1912-2, which has enhanced productivity, is more resistant to anthracyclines. Strains 1912, 29050, 27925 have similar antibiotic resistance spectra. Eryr - mutants of S. globisporus appear to be resistant simultaneously to so called MLS-antibiotics. Resistance to MLS-antibiotics is induced in wild type and optimal conditions for induction were determined. Induction of resistance in Eryr mutants were not ībserved.
Key words: Streptomyces, antibiotics, resistance to antibiotics.
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