THE INFLUENCE OF SODIUM ALPHA-KETOGLUTARATE ON
AMINOTRANSFERASE AND SUCCINATEDEHIDROGENASE ACTIVITY IN
HEPAR OF RATS WITH DIFFERENT RESISTANCE TO HYPOXIA AFTER
DYNAMIC ENDURANCE
N. Kurgalyuk, O.Vernyuk, M.Galkiv
Ivan Franko National University of Lviv, Hryshevsky³ Str., 4
UA-79005 Lviv, Ukraine. E-mail:biolog@franko.lviv.ua
The studies have been performed in high- (HR) and low-resistant (LR) to hypoxia animals swimming to the point of exhaustion. It has been established that HR rats are capable to endure the dynamic load twice longer. The introduction of SKG increases the endurance of LR animals to the level of the HR ones, activates the aminotransferase mechanisms of ketoglutarate supply as an oxidation substrate against the background of decreased tissue succinic dehydrogenase activity. Such functional reorganization in a body is directed to decreasing the energy expenses in HR and LR animals under the relevant sidnificant functional loads and restriction of the influence of lipid peroxidation products (determined by blood and tissue concentration of malonic dialdehyde) to cellular membrane.
Key words: sodium alpha-ketoglutarate, aminotransferase, succinatedehidrogenase, resistance to hypoxia, dynamic endurance.
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