INFLUENCE OF L-ARGININE AND NITRIC OXIDE SYNTHASE INHIBITOR L -NNA
ON THE CONDITION OF MITOCHONDRIAL CALCIUM CAPACITY IN THE LIVERS OF RATS
WITH DIFFERENT RESISTANCE TO HYPOXIA UNDER STRESS CONDITIONS
N. Kurhalyuk, O. Ikkert, O. Horyn, M. Galkiv, S. Hordii
Ivan Franko National University of L'viv,
Hrushevskoho st. 4, L'viv 79005, Ukraine,
e-mail: biolog@franko.lviv.ua
We investigated the influence of L-arginine and nitric oxide synthase inhibitor L-NNA on condition of mitochondrial calcium capacity in the liver of Wistar rats with different resistance to hypoxia by using such substrata of energy support: succinic, alpha-ketoglutaric acids in stress conditions. It was shown that L-arginine injection reduces mitochondrial calcium capacity in low resistance rats by using succinate and alpha-ketoglutarate. NO-synthase inhibitor L-NNA limits effects of L-arginine influence on these processes.
Key words: L-arginine, NO-synthase blockator L-NNA, calcium mitochondrial capacity.
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