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THE CHARACTERIZATION OF STREPTOMYCES PEUCETIUS
SUSP. CAESIUS ATCC 27952-2 MUTANTS RESISTANT TO
CHLORAMPHENICOL
L. Dubytska, V. Fedorenko
Ivan Franko National University of L’viv,
Hrushevskoho st. 4, L’viv 79005, Ukraine,
e-mail: genetic@franko.lviv.ua
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The antibiotic activity level and resistance to antibiotics of
the strain Streptomyces peucetius subsp. caesius ATCC 27952-2 and its
chloramphenicol- resistant mutants have been investigated. Cmlr- mutants
demonstrate decreased total antibiotic activity in comparison to strain
27952-2. However 92,8% Cmlr-mutants, obtained after N-metyl-N/-
nitro-N-nitrozoguanidin treatment of strain 27952-2 synthesized DXR and its
intermediates. Two mutants among them are characterized by increasing of DXR
production level (1,8-2 fold in comparison to initial strain 27952-2).
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Keywords: Streptomyces peucetius, antibiotic activity, resistance to
chloramphenicol.
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