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THE INFLUENCE OF L-ARGININE AND Nw-NITRO - LARGININE
ON ENERGY METABOLISM OF RATS LIVER
MITOCHONDRIA WITH DIFFERENT RESISTANCE TO
HYPOXIA UNDER STRESS CONDITION
O. Ikkert, N. Kurhalyuk, S. Hordii
Ivan Franko National University of L’viv,
Hrushevskoho st. 4, L’viv 79005, Ukraine,
e-mail: biolog@franko.lviv.ua
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It was investigated the influence of L-arginine (600 mg/kg)
and NO-synthase blocator N -nitro-L-arginine L-NNA (35mg/kg) on processes of
ADP-stimulated respiration of rats liver mitochondria with different resistance
to hypoxia under stress conditions. It have been shown that energy metabolism
indices are higher in HR animals in control group. Stress causes increasing of
ADP-stimulated respiration in LR under succinate oxidation and decreasing of
NADPH-dependent utilisation, indicative of more effort of energy system in LR
animals. L-arginine injection decreas es the aerobi c link of energy metabolism
in LR under oxidation as succinat e as a-ketoglutarate. Treatment with L-NNA
causes increasing the energy metabolism in HR under a-ketoglutarate oxidation.
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Keywords: L-arginine, Nw -nitro-L-arginine, energy metabolism, hypoxia,
stress.
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