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CASOKININS AS ANTIHYPERTENSIVE PEPTIDES DERIVED
FROM MILK CASEINS
B. Luhovyy, V. Yukalo
Ivan Puluj Technical State University ща Ternopil’,
Rus’ka str., 56, Ternopil’ 46001, Ukraine,
e-mail: biotech@tu.edu.te.ua
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The angiotensin-converting enzyme inhibitory peptides derived from milk proteins
can to act as antihypertensive drugs in vivo. These peptides named casokinins can be obtained
after proteolysis of αs1-, β- and κ-caseins by digestive enzyme and lactic-acid
bacteria proteases or by synthesis. The casokinins were detected in skim milk products
and in famous cheeses. It is possible to use the selected strains of lactic-acid bacteria and
ACE-inhibitory peptides supplement for milk products making with antihypertensive
activity.
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Keywords: casokinins, caseins, ACE-inhibitors, and hypertension.
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